Synthetic lethality is a proven effective antitumor strategy that has attracted great attention.Large-scale screening ha......

目的 Cyclin dependent kinase 1 (CDK1) is an essential kinase that involves in a wide range of biological processes which......

Synthetic lethal screening,which exploits the combination of mutations that result in cell death,is a promising method f......

25%的肿瘤存在RAS基因突变,RAS基因突变是非小细胞肺癌中最常见的突变基因,其中在肺腺癌中K-RAS突变占RAS突变的90%.直接抑制K-RAS......